Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of mouse TGF-a induction in saccular phase and alveolar phase lung morphogenesis in mice

ABSTRACT: Effect of TGFa induction on saccular phase or alveolar phase lung morphogenesis in mice.

INSTRUMENT(S): Axon GenePix 4000B scanning hardware

ORGANISM(S): Mus musculus

SUBMITTER: Machiko Ikegami 

PROVIDER: E-MEXP-698 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis.

Kramer Elizabeth L EL   Deutsch Gail H GH   Sartor Maureen A MA   Hardie William D WD   Ikegami Machiko M   Korfhagen Thomas R TR   Le Cras Timothy D TD  

American journal of physiology. Lung cellular and molecular physiology 20070427 2

Transforming growth factor-alpha (TGF-alpha) and its receptor, the epithelial growth factor receptor (EGFR), have been associated with lung remodeling in premature infants with bronchopulmonary dysplasia (BPD). The goal of this study was to target TGF-alpha overexpression to the saccular phase of lung morphogenesis and determine early alterations in gene expression. Conditional lung-specific TGF-alpha bitransgenic mice and single-transgene control mice were generated. TGF-alpha overexpression wa  ...[more]

Similar Datasets

no omics defined Transcription profiling of lung from mice with doxycycline-induced TGFa-over-expression for 6 up to weeks, and up to 6 weeks of recovery to study TGFa-induced pulmonary fibrosis
2007-05-23 | E-MEXP-966 | biostudies-arrayexpress
Transcriptomics Transcription profiling of C3H/HeJ and JF1/Msf strain mice to identify genetic risk factors for asthma and COPD
2007-03-08 | E-MEXP-855 | biostudies-arrayexpress
Transcriptomics Transcription profiling of wild type and Ahr(-/-) mouse embryo fibroblast cells
2006-10-17 | E-MEXP-787 | biostudies-arrayexpress
Transcriptomics Transcription profiling of mouse T cell sub-populations isolated from pulmonary tissue after mice were exposured to filtered air of acrolein for one week
2008-11-15 | E-MEXP-1354 | biostudies-arrayexpress
Transcriptomics Transcription profiling of dox-inducible, bitransgenic Ccsp-rtta x Teto-fgf7 mice lungs to 1 and 3 days of doxycycline treatment
2022-11-22 | E-MEXP-644 | biostudies-arrayexpress
Transcriptomics Transcription profiling of mouse fibroblasts expressing the 57Bl/6 Ah-receptor vs. Ahr-/- fibroblasts synchronized at G0/G1, S-phase, and in exponential growth
2007-08-05 | E-MEXP-996 | biostudies-arrayexpress
Transcriptomics Transcription profiling of mouse activin treated MEKK1 wild type and KO keratinocytes
2007-11-20 | E-MEXP-355 | biostudies-arrayexpress
Transcriptomics Transcription profiling of lung from wild type and Mt1(-/-)Mt2(-/-) double knock-out mice after nickel aerosol exposure for 3, 8, 24, 48, and 72 hrs
2006-08-02 | E-MEXP-816 | biostudies-arrayexpress
Transcriptomics Transcription profiling of mouse placenta to determine the relative effects of maternal and fetal genotype on the placental transcriptome at E18.5
2010-08-06 | E-MEXP-2479 | biostudies-arrayexpress
Transcriptomics Transcription profiling of Puga- tBHQ and arsenic treated GCLM-WT and KO mice
2005-12-08 | E-MEXP-371 | biostudies-arrayexpress