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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of wild type and Ahr(-/-) mouse embryo fibroblast cells

ABSTRACT: Wildtype vs. Ahr(-/-) mouse embryo fibroblast cells were compared in a flipped-dye design

INSTRUMENT(S): Axon GenePix 4000B scanning hardware

ORGANISM(S): Mus musculus

SUBMITTER: Scott Wesselkamper

PROVIDER: E-MEXP-787 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments.

Sartor Maureen A MA Tomlinson Craig R CR Wesselkamper Scott C SC Sivaganesan Siva S Leikauf George D GD Medvedovic Mario M

BMC bioinformatics 20061219

<h4>Background</h4>The small sample sizes often used for microarray experiments result in poor estimates of variance if each gene is considered independently. Yet accurately estimating variability of gene expression measurements in microarray experiments is essential for correctly identifying differentially expressed genes. Several recently developed methods for testing differential expression of genes utilize hierarchical Bayesian models to "pool" information from multiple genes. We have develo ...[more]

PMID: 17177995

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