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Transcription profiling of C3H/HeJ and JF1/Msf strain mice to identify genetic risk factors for asthma and COPD

ABSTRACT: Comparison of lung function in C3H/HeJ and JF1/Msf strain mice to identify genetic risk factors for asthma and COPD.

INSTRUMENT(S): Axon GenePix 4000B scanning hardware

ORGANISM(S): Mus musculus

SUBMITTER: Mario Medvedovic 

PROVIDER: E-MEXP-855 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Candidate genes controlling pulmonary function in mice: transcript profiling and predicted protein structure.

Ganguly Koustav K   Stoeger Tobias T   Wesselkamper Scott C SC   Reinhard Claudia C   Sartor Maureen A MA   Medvedovic Mario M   Tomlinson Craig R CR   Bolle Ines I   Mason John M JM   Leikauf George D GD   Schulz Holger H  

Physiological genomics 20070905 3

Impaired development and reduced lung capacity are risk factors of asthma and chronic obstructive pulmonary disease. Previously, our genomewide linkage analysis of C3H/HeJ (C3H) and JF1/Msf (JF1) mouse strains identified quantitative trait loci (QTLs) associated with the complex traits of dead space volume (Vd), total lung capacity (TLC), lung compliance (CL), and diffusing capacity for CO (D(CO)). We assessed positional candidate genes by comparing C3H with JF1 lung transcript levels by microar  ...[more]

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