Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of lung from mice with doxycycline-induced TGFa-over-expression for 6 up to weeks, and up to 6 weeks of recovery to study TGFa-induced pulmonary fibrosis

ABSTRACT: Time series response to Doxycycline-induced TGFa-overexpression for 6 up to weeks, and up to 6 weeks of recovery.

INSTRUMENT(S): Axon GenePix 4000B scanning hardware

ORGANISM(S): Mus musculus

SUBMITTER: Maureen Sartor 

PROVIDER: E-MEXP-966 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.

Hardie William D WD   Korfhagen Thomas R TR   Sartor Maureen A MA   Prestridge Adrienne A   Medvedovic Mario M   Le Cras Timothy D TD   Ikegami Machiko M   Wesselkamper Scott C SC   Davidson Cynthia C   Dietsch Maggie M   Nichols William W   Whitsett Jeffrey A JA   Leikauf George D GD  

American journal of respiratory cell and molecular biology 20070511 3

Expression of transforming growth factor alpha (TGF-alpha) in the respiratory epithelium of transgenic mice caused pulmonary fibrosis, cachexia, pulmonary hypertension, and altered lung function. To identify genes and molecular pathways mediating lung remodeling, mRNA microarray analysis was performed at multiple times after TGF-alpha expression and revealed changes consistent with a role for TGF-alpha in the regulation of extracellular matrix and vasculogenesis. Transcripts for extracellular ma  ...[more]

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