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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human Cystic Fibrosis cell line and a control cell line

ABSTRACT: comparison of expression profiles between a cystic fibrosis cell line and a control cell line

ORGANISM(S): Homo sapiens

SUBMITTER: Catherine Verhaeghe

PROVIDER: E-MEXP-980 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Role of IKK and ERK pathways in intrinsic inflammation of cystic fibrosis airways.

Verhaeghe Catherine C Remouchamps Caroline C Hennuy Benoît B Vanderplasschen Alain A Chariot Alain A Tabruyn Sebastien P SP Oury Cecile C Bours Vincent V

Biochemical pharmacology 20070324 12

In cystic fibrosis (CF) patients, pulmonary inflammation is a major cause of morbidity and mortality and may precede bacterial colonization. The aim of the present study was to investigate the molecular mechanisms underlying intrinsic inflammation in cystic fibrosis airways. Using different cystic fibrosis cell models, we first demonstrated that, beside a high constitutive nuclear factor of kappaB (NF-kappaB) activity, CF cells showed a higher activator protein-1 (AP-1) activity as compared to t ...[more]

PMID: 17466952

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