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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Microarray expression profiling of male and female bone marrow derived macrophages from wild type and lysMCre/Irf2bp2flox mice

ABSTRACT: Interferon regulatory factor 2 binding protein 2 (Irf2bp2) is a corepressor of Irf2 that suppresses inflammatory gene expression and promotes the M2 macrophage phenotype in bone marrow derived macrophages (BMDM). Loss of Irf2bp2 in male macrophages promotes an inflammatory phenotype. Here, we compared the expression profile of female BMDM to their male counterparts to identify genes differentially affected by the loss of Irf2bp2 by sex in primary macrophages cultured under basal conditions.

ORGANISM(S): Mus musculus domesticus

SUBMITTER: Alexandre Stewart

PROVIDER: E-MTAB-14166 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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IRF2BP2 Reduces Macrophage Inflammation and Susceptibility to Atherosclerosis.

Chen Hsiao-Huei HH Keyhanian Kianoosh K Zhou Xun X Vilmundarson Ragnar O RO Almontashiri Naif A M NA Cruz Shelly A SA Pandey Nihar R NR Lerma Yap Nida N Ho Tiffany T Stewart Chloe A CA Huang Hua H Hari Aswin A Geoffrion Michele M McPherson Ruth R Rayner Katey J KJ Stewart Alexandre F R AF

Circulation research 20150720 8

<h4>Rationale</h4>Inflammation impairs macrophage cholesterol clearance from vascular tissues and promotes atherosclerosis. Inflammatory macrophages suppress expression of the transcription cofactor interferon regulatory factor 2-binding protein 2 (IRF2BP2), and genetic variants near IRF2BP2 associate with ischemic heart disease progression in humans.<h4>Objectives</h4>To test whether IRF2BP2 in macrophages affects atherosclerosis in mice and humans.<h4>Methods and results</h4>We generated mice ...[more]

PMID: 26195219

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