Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Iris de Rink
PROVIDER: E-MTAB-1772 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Peperzak Victor V Veraar Elise A M EA Xiao Yanling Y Babala Nikolina N Thiadens Klaske K Brugmans Marieke M Borst Jannie J
Journal of immunology (Baltimore, Md. : 1950) 20130812 6
Various cell types can produce the chemokine CXCL10 in response to IFN-γ stimulation. CXCL10 is generally viewed as a proinflammatory chemokine that promotes recruitment of CD8÷ and Th1-type CD4÷ effector T cells to infected or inflamed nonlymphoid tissues. We show that CXCL10 plays a role during CD8÷ T cell priming in the mouse. Genome-wide expression profiling revealed the Cxcl10 gene as a target of CD27/CD70 costimulation in newly activated CD8÷ T cells. CD27/CD70 costimulation is known to pr ...[more]