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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profile of induced transgenic AhCreICDE/wt and AhCreEYFP/wt mice small intestine

ABSTRACT: Transgenic AhCreICDE/WT (n=3) and AhCreEYFP/WT (n=3) mice were induced with 3x80mg/kg betanapthoflavone and culled 24 hours later. RNA was extracted from the small intestine and hybridised to an Illumina mouseWG6 bead array

ORGANISM(S): Mus musculus

SUBMITTER: Joanna Fowler

PROVIDER: E-MTAB-543 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Intestinal activation of Notch signaling induces rapid onset hepatic steatosis and insulin resistance.

Fowler Joanna C JC Zecchini Vincent R VR Jones Philip H PH

PloS one 20110616 6

Here we investigate the effects of expressing an activated mutant of Notch (ICD-E) in an inducible transgenic mouse model. Hepatic expression of ICD-E in adult animals has no detectable phenotype, but simultaneous induction of ICD-E in both the liver and small intestine results in hepatic steatosis, lipogranuloma formation and mild insulin resistance within 96 hours. This supports work that suggests that fatty liver disease may result from disruption of the gut-liver axis. In the intestine, ICD- ...[more]

PMID: 21698231

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Transcription profling of human embryonic stem cells differentiated into endoderm progenitors in chemically-defined media.

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