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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human BRAFE600-expressing, senescent fibroblast cells that have bypassed oncogene-induced senescence by depletion of C/EBPb a

ABSTRACT: Analysis of BRAFE600-expressing, senescent cells, and bypass from OIS by depletion of C/EBPb and IL-6

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Kuilman

PROVIDER: E-NCMF-13 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

Kuilman Thomas T Michaloglou Chrysiis C Vredeveld Liesbeth C W LC Douma Sirith S van Doorn Remco R Desmet Christophe J CJ Aarden Lucien A LA Mooi Wolter J WJ Peeper Daniel S DS

Cell 20080601 6

Oncogene-induced cellular senescence (OIS) is emerging as a potent cancer-protective response to oncogenic events, serving to eliminate early neoplastic cells from the proliferative pool. Using combined genetic and bioinformatic analysis, we find that OIS is linked specifically to the activation of an inflammatory transcriptome. Induced genes included the pleiotropic cytokine interleukin-6 (IL-6), which upon secretion by senescent cells acted mitogenically in a paracrine fashion. Unexpectedly, I ...[more]

PMID: 18555778

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