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Transcription profiling of lungs of C3H mice infected with Bordetella and mock control

ABSTRACT: Transcriptional responses in lungs of C3H mice infected with Bordetella and mock control

ORGANISM(S): Mus musculus

DISEASE(S): Bordetella pertussis inoculated

SUBMITTER: Jeroen Pennings

PROVIDER: E-TABM-266 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Lung response to Bordetella pertussis infection in mice identified by gene-expression profiling.

Banus Sander S Pennings Jeroen J Vandebriel Rob R Wester Piet P Breit Timo T Mooi Frits F Hoebee Barbara B Kimman Tjeerd T

Immunogenetics 20070509 7

Host genetics determines the course of Bordetella pertussis infection in mice. Previously, we found four loci, Tlr4 and three novel loci, designated Bps 1-3, that are involved in the control of B. pertussis infection. The purpose of the present study was to identify candidate genes that could explain genetic differences in the course of B. pertussis infection, assuming that such genes are differentially regulated upon infection. We, therefore, studied the course of mRNA expression in the lungs a ...[more]

PMID: 17487483

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