Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Comparative genomic hybridization of 137 Bordetella pertussis strains

ABSTRACT: Comparative genome hybridization (CGH) of sample of 137 Bordetella pertussis strains

INSTRUMENT(S): Scanning hardware

ORGANISM(S): Bordetella pertussis

SUBMITTER: Craig Cummings 

PROVIDER: E-TABM-54 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Significant gene order and expression differences in Bordetella pertussis despite limited gene content variation.

Brinig Mary M MM   Cummings Craig A CA   Sanden Gary N GN   Stefanelli Paola P   Lawrence Andrew A   Relman David A DA  

Journal of bacteriology 20060401 7

Bordetella pertussis, an obligate human pathogen and the agent of whooping cough, is a clonal species, despite the dynamic selection pressures imposed by host immunity and vaccine usage. Because the generation of variation is critical for species evolution, we employed a variety of approaches to examine features of B. pertussis genetic variation. We found a high level of conservation of gene content among 137 B. pertussis strains with different geographical, temporal, and epidemiological associa  ...[more]

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