Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse G1ME cells following retroviral infection and shRNA-mediated knock-down of Suz12 and Ezh2


ABSTRACT: Suz12 in hematopoiesis II. Retroviral Infection and shRNA-mediated knock-down of Suz12 and Ezh2 in mouse G1ME cells.

ORGANISM(S): Mus musculus

SUBMITTER: Carolyn de Graaf 

PROVIDER: E-TABM-396 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Polycomb group proteins are transcriptional repressors that play a central role in the establishment and maintenance of gene expression patterns during development. Using mice with an N-ethyl-N-nitrosourea (ENU)-induced mutation in Suppressor of Zeste 12 (Suz12), a core component of Polycomb Repressive Complex 2 (PRC2), we show here that loss of Suz12 function enhances hematopoietic stem cell (HSC) activity. In addition to these effects on a wild-type genetic background, mutations in Suz12 are s  ...[more]

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