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Transcription profiling of kuk and kur depleted embryos of Drosophila

ABSTRACT: Expression profile of Drosophila wild-type embryos in comparison to wild-type embryos injected with kuk dsRNA and embryos from kur germline clones. The stage of the embryos was late stage 5/stage 6/early stage 7 (late cellularisation/early gastrulation before germband extension). Four independent wild-type, two kuk and two kur embryo collections were performed. Total RNA was extracted and amplified. Mutant and respective wildtype samples were hybridized together on INDAC oligo arrays.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Charles Girardot

PROVIDER: E-TABM-75 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Developmental control of nuclear size and shape by Kugelkern and Kurzkern.

Brandt Annely A Papagiannouli Fani F Wagner Nicole N Wilsch-Bräuninger Michaela M Braun Martina M Furlong Eileen E EE Loserth Silke S Wenzl Christian C Pilot Fanny F Vogt Nina N Lecuit Thomas T Krohne Georg G Grosshans Jörg J

Current biology : CB 20060202 6

<h4>Background</h4>The shape of a nucleus depends on the nuclear lamina, which is tightly associated with the inner nuclear membrane and on the interaction with the cytoskeleton. However, the mechanism connecting the differentiation state of a cell to the shape changes of its nucleus are not well understood. We investigated this question in early Drosophila embryos, where the nuclear shape changes from spherical to ellipsoidal together with a 2.5-fold increase in nuclear length during cellulariz ...[more]

PMID: 16458513

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