Dataset Information
Transcription profiling by array of yeast wild type strains compared to a reference pool
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Patrick Kemmeren
PROVIDER: E-TABM-984 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Large-scale genetic perturbations reveal regulatory networks and an abundance of gene-specific repressors.
Cell 20140401 3
To understand regulatory systems, it would be useful to uniformly determine how different components contribute to the expression of all other genes. We therefore monitored mRNA expression genome-wide, for individual deletions of one-quarter of yeast genes, focusing on (putative) regulators. The resulting genetic perturbation signatures reflect many different properties. These include the architecture of protein complexes and pathways, identification of expression changes compatible with viabili ...[more]
