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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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S. cerevisiae time-course in the presence of 100uM BCS

ABSTRACT: Saccharomyces cerevisiae cells were exposed to a copper chelator (100uM BCS) for 48 hours. Samples were compared to the zero hour timepoint at 0.5, 1, 2, 3, 4, 24 and 48 hours.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Eric Strengman

PROVIDER: E-UMCU-16 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling and phenotype analyses of S. cerevisiae in response to changing copper reveals six genes with new roles in copper and iron metabolism.

van Bakel Harm H Strengman Eric E Wijmenga Cisca C Holstege Frank C P FC

Physiological genomics 20050510 3

Exhaustive microarray time course analyses of Saccharomyces cerevisiae during copper starvation and copper excess reveal new aspects of metal-induced gene regulation. Aside from identifying targets of established copper- and iron-responsive transcription factors, we find that genes encoding mitochondrial proteins are downregulated and that copper-independent iron transport genes are preferentially upregulated, both during prolonged copper deprivation. The experiments also suggest the presence of ...[more]

PMID: 15886332

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