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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Wild type versus reference pool

ABSTRACT: Wild type versus reference pool. Reference pools from either the CuSO4 or BCS timecourse were compared with wildtype cells taken from mid-log cultures.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Eric Strengman

PROVIDER: E-UMCU-17 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling and phenotype analyses of S. cerevisiae in response to changing copper reveals six genes with new roles in copper and iron metabolism.

van Bakel Harm H Strengman Eric E Wijmenga Cisca C Holstege Frank C P FC

Physiological genomics 20050510 3

Exhaustive microarray time course analyses of Saccharomyces cerevisiae during copper starvation and copper excess reveal new aspects of metal-induced gene regulation. Aside from identifying targets of established copper- and iron-responsive transcription factors, we find that genes encoding mitochondrial proteins are downregulated and that copper-independent iron transport genes are preferentially upregulated, both during prolonged copper deprivation. The experiments also suggest the presence of ...[more]

PMID: 15886332

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