Ontology highlight
ABSTRACT:
SUBMITTER: Ray S
PROVIDER: S-EPMC1592460 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Biological procedures online 20060731
Chromatin immunoprecipitation (ChIP) technique allows detection of proteins that bind to chromatin. While this technique has been applied extensively in cell-based studies, its tissue-based application remains poorly explored. We are specifically interested in examining estrogen-dependent transcriptional mechanism in respect of recruitment of estrogen receptor-alpha (ERalpha), a ligand-activated transcription factor, to uterine gene promoters in mice. Recent gene-array studies, utilizing ERalpha ...[more]