Ontology highlight
ABSTRACT:
SUBMITTER: Alphey MS
PROVIDER: S-EPMC2552391 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Alphey Magnus S MS König Janine J Fairlamb Alan H AH
The Biochemical journal 20080901 3
TbTDPX (Trypanosoma brucei tryparedoxin-dependent peroxidase) is a genetically validated drug target in the fight against African sleeping sickness. Despite its similarity to members of the GPX (glutathione peroxidase) family, TbTDPX2 is functional as a monomer, lacks a selenocysteine residue and relies instead on peroxidatic and resolving cysteine residues for catalysis and uses tryparedoxin rather than glutathione as electron donor. Kinetic studies indicate a saturable Ping Pong mechanism, unl ...[more]