Ontology highlight
ABSTRACT:
SUBMITTER: Gratton SE
PROVIDER: S-EPMC2575324 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Gratton Stephanie E A SE Ropp Patricia A PA Pohlhaus Patrick D PD Luft J Christopher JC Madden Victoria J VJ Napier Mary E ME DeSimone Joseph M JM
Proceedings of the National Academy of Sciences of the United States of America 20080812 33
The interaction of particles with cells is known to be strongly influenced by particle size, but little is known about the interdependent role that size, shape, and surface chemistry have on cellular internalization and intracellular trafficking. We report on the internalization of specially designed, monodisperse hydrogel particles into HeLa cells as a function of size, shape, and surface charge. We employ a top-down particle fabrication technique called PRINT that is able to generate uniform p ...[more]