Ontology highlight
ABSTRACT:
SUBMITTER: Kolonko EM
PROVIDER: S-EPMC3216674 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Kolonko Erin M EM Kiessling Laura L LL
Journal of the American Chemical Society 20080408 17
Polymers have emerged as powerful biological tools; however, their ability to gain access to the intracellular environment is limited. To expand the biological utility of polymer scaffolds, we have synthesized an internalization domain using the ring-opening metathesis polymerization (ROMP). A polymer functionalized with guanidinium groups is effectively internalized by cells and localized in both vesicles and the cytoplasm. Because the synthesis of such materials is modular, we anticipate that ...[more]