Ontology highlight
ABSTRACT:
SUBMITTER: Gupta SM
PROVIDER: S-EPMC2607029 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Gupta Sadhana M SM Aranha Clara C CC Mohanty Madhu C MC Reddy K V R KV
Mediators of inflammation 20081222
Topical microbicides are intended for frequent use by women in reproductive age. Hence, it is essential to evaluate their impact on mucosal immune function in the vagina. In the present study, we evaluated nisin, a naturally occurring antimicrobial peptide (AMP), for its efficacy as an intravaginal microbicide. Its effect on the vaginal immune function was determined by localizing Toll-like receptors (TLRs-3, 9) and cytokines (IL-4, 6 , 10 and TNF-alpha) in the rabbit cervicovaginal epithelium f ...[more]