Ontology highlight
ABSTRACT:
SUBMITTER: Cooper JD
PROVIDER: S-EPMC2635556 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Cooper Jason D JD Smyth Deborah J DJ Smiles Adam M AM Plagnol Vincent V Walker Neil M NM Allen James E JE Downes Kate K Barrett Jeffrey C JC Healy Barry C BC Mychaleckyj Josyf C JC Warram James H JH Todd John A JA
Nature genetics 20081102 12
We carried out a meta-analysis of data from three genome-wide association (GWA) studies of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ancestry. We obtained further support for 4q27 (IL2-IL21, P = 1.9 x 10(-8)) and, after genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing evidence for four previously unknown and distinct risk loci in chromosome regions 6q15 (BACH2, P = 4.7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9 ...[more]