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Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.


ABSTRACT: We carried out a meta-analysis of data from three genome-wide association (GWA) studies of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ancestry. We obtained further support for 4q27 (IL2-IL21, P = 1.9 x 10(-8)) and, after genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing evidence for four previously unknown and distinct risk loci in chromosome regions 6q15 (BACH2, P = 4.7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8)).

SUBMITTER: Cooper JD 

PROVIDER: S-EPMC2635556 | biostudies-literature | 2008 Dec

REPOSITORIES: biostudies-literature

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Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

Cooper Jason D JD   Smyth Deborah J DJ   Smiles Adam M AM   Plagnol Vincent V   Walker Neil M NM   Allen James E JE   Downes Kate K   Barrett Jeffrey C JC   Healy Barry C BC   Mychaleckyj Josyf C JC   Warram James H JH   Todd John A JA  

Nature genetics 20081102 12


We carried out a meta-analysis of data from three genome-wide association (GWA) studies of type 1 diabetes (T1D), testing 305,090 SNPs in 3,561 T1D cases and 4,646 controls of European ancestry. We obtained further support for 4q27 (IL2-IL21, P = 1.9 x 10(-8)) and, after genotyping an additional 6,225 cases, 6,946 controls and 2,828 families, convincing evidence for four previously unknown and distinct risk loci in chromosome regions 6q15 (BACH2, P = 4.7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9  ...[more]

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