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Total synthesis of phomactin A.


ABSTRACT: A total synthesis of (+/-)-phomactin A is described to highlight the final completion of a complex natural product target that had commenced with an intramolecular oxa-[3 + 3] annulation strategy in the construction of the ABD-tricycle. These efforts reveal structural intricacies of this ABD-tricycle with an illustrative example being the conformational analysis that was ultimately critical for the C5a-homolgation.

SUBMITTER: Tang Y 

PROVIDER: S-EPMC2701356 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

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Total synthesis of phomactin A.

Tang Yu Y   Cole Kevin P KP   Buchanan Grant S GS   Li Gang G   Hsung Richard P RP  

Organic letters 20090401 7


A total synthesis of (+/-)-phomactin A is described to highlight the final completion of a complex natural product target that had commenced with an intramolecular oxa-[3 + 3] annulation strategy in the construction of the ABD-tricycle. These efforts reveal structural intricacies of this ABD-tricycle with an illustrative example being the conformational analysis that was ultimately critical for the C5a-homolgation. ...[more]

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