Ontology highlight
ABSTRACT:
SUBMITTER: Schrader CE
PROVIDER: S-EPMC275407 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Schrader Carol E CE Bradley Sean P SP Vardo Joycelyn J Mochegova Sofia N SN Flanagan Erin E Stavnezer Janet J
The EMBO journal 20031101 21
Nucleotide substitutions are found in recombined Ig switch (S) regions and also in unrecombined (germline, GL) Smicro segments in activated splenic B cells. Herein we examine whether mutations are also introduced into the downstream acceptor S regions prior to switch recombination, but find very few mutations in GL Sgamma3 and Sgamma1 regions in activated B cells. These data suggest that switch recombination initiates in the Smicro segment and secondarily involves the downstream acceptor S regio ...[more]