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Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups.

ABSTRACT: A continuous flow system for the synthesis of enantioenriched diarylmethanols from aldehydes is described. The system uses an amino alcohol-functionalized polystyrene resin as the catalyst, and the arylating agent is conveniently prepared by transmetallation of triarylboroxins with diethylzinc.

SUBMITTER: Rolland J

PROVIDER: S-EPMC2813714 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups.

Rolland Julien J Cambeiro Xacobe C XC Rodríguez-Escrich Carles C Pericàs Miquel A MA

Beilstein journal of organic chemistry 20091015

A continuous flow system for the synthesis of enantioenriched diarylmethanols from aldehydes is described. The system uses an amino alcohol-functionalized polystyrene resin as the catalyst, and the arylating agent is conveniently prepared by transmetallation of triarylboroxins with diethylzinc. ...[more]

PMID: 20126636

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