Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC2865226 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Liu Y Y Sundberg J P JP Das S S Carpenter D D Cain K T KT Michaud E J EJ Voy B H BH
Veterinary pathology 20100101 1
Animal models carrying mutations in the hairless (Hr) gene provide a rich resource for study of hair follicle biology. A spontaneous mouse mutant with a phenotype strikingly similar to rhino mutants of Hr arose spontaneously in the mouse facility at Oak Ridge National Laboratory. Sequence analysis of Hr in these mutants uncovered a nonsense mutation in exon 12, designated as Hr(rh-R) (rhino, Oak Ridge). The mutation led to significant reduction in Hr mRNA levels, predicted to be due to nonsense- ...[more]