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?-Polymorph of phenazepam: a powder study.

ABSTRACT: THE TITLE COMPOUND [SYSTEMATIC NAME: 7-bromo-5-(2-chloro-phen-yl)-1H-1,4-benzodiazepin-2(3H)-one] (?-polymorph), C(15)H(10)BrClN(2)O, has been obtained via cryomodification of the known ?-polymorph of phenazepam [Karapetyan et al. (1979 ?). Bioorg. Khim.5, 1684-1690]. In both polymorphs, the mol-ecules, which differ only in the dihedral angles between the aromatic rings [75.4?(2)° and 86.2?(3)° in the ?- and ?-polymorphs, respectively], are linked into centrosymmetric dimers via N-H?O hydrogen bonds. In the crystal structure of the ?-polymorph, weak inter-molecular C-H?O hydrogen bonds further link these dimers into layers parallel to bc plane.

SUBMITTER: Sergeev GB

PROVIDER: S-EPMC2983154 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature

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β-Polymorph of phenazepam: a powder study.

Sergeev Gleb B GB Sergeev Boris M BM Morosov Yurii N YN Chernyshev Vladimir V VV

Acta crystallographica. Section E, Structure reports online 20100925 Pt 10

THE TITLE COMPOUND [SYSTEMATIC NAME: 7-bromo-5-(2-chloro-phen-yl)-1H-1,4-benzodiazepin-2(3H)-one] (β-polymorph), C(15)H(10)BrClN(2)O, has been obtained via cryomodification of the known α-polymorph of phenazepam [Karapetyan et al. (1979 ▶). Bioorg. Khim.5, 1684-1690]. In both polymorphs, the mol-ecules, which differ only in the dihedral angles between the aromatic rings [75.4 (2)° and 86.2 (3)° in the α- and β-polymorphs, respectively], are linked into centrosymmetric dimers via N-H⋯O hydrogen b ...[more]

PMID: 21587597

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