Ontology highlight
ABSTRACT:
SUBMITTER: Ben-Zeev O
PROVIDER: S-EPMC3090237 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Ben-Zeev Osnat O Hosseini Maryam M Lai Ching-Mei CM Ehrhardt Nicole N Wong Howard H Cefalù Angelo B AB Noto Davide D Averna Maurizio R MR Doolittle Mark H MH Péterfy Miklós M
Journal of lipid research 20110328 6
Lipase maturation factor 1 (Lmf1) is an endoplasmic reticulum (ER) membrane protein involved in the posttranslational folding and/or assembly of lipoprotein lipase (LPL) and hepatic lipase (HL) into active enzymes. Mutations in Lmf1 are associated with diminished LPL and HL activities ("combined lipase deficiency") and result in severe hypertriglyceridemia in mice as well as in human subjects. Here, we investigate whether endothelial lipase (EL) also requires Lmf1 to attain enzymatic activity. W ...[more]