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Anti-Inflammatory Cembranoids from a Formosa Soft Coral Sarcophyton cherbonnieri.


ABSTRACT: The present investigation on chemical constituents of the soft coral Sarcophyton cherbonnieri resulted in the isolation of seven new cembranoids, cherbonolides F-L (1-7). The chemical structures of 1-7 were determined by spectroscopic methods, including infrared, one- and two-dimensional (1D and 2D) NMR (COSY, HSQC, HMBC, and NOESY), MS experiments, and a chemical reduction of hydroperoxide by triphenylphosphine. The anti-inflammatory activities of 1-7 against neutrophil proinflammatory responses were evaluated by measuring their inhibitory ability toward N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced superoxide anion generation and elastase release in primary human neutrophils. The results showed that all isolates exhibited moderate activities, while cherbonolide G (2) and cherbonolide H (3) displayed a more active effect than others on the inhibition of elastase release (48.2% ± 6.2%) and superoxide anion generation (44.5% ± 4.6%) at 30 µM, respectively.

SUBMITTER: Peng CC 

PROVIDER: S-EPMC7699541 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Anti-Inflammatory Cembranoids from a Formosa Soft Coral <i>Sarcophyton cherbonnieri</i>.

Peng Chia-Chi CC   Huang Chiung-Yao CY   Ahmed Atallah F AF   Hwang Tsong-Long TL   Sheu Jyh-Horng JH  

Marine drugs 20201119 11


The present investigation on chemical constituents of the soft coral <i>Sarcophyton cherbonnieri</i> resulted in the isolation of seven new cembranoids, cherbonolides F-L (<b>1</b>-<b>7</b>). The chemical structures of <b>1</b>-<b>7</b> were determined by spectroscopic methods, including infrared, one- and two-dimensional (1D and 2D) NMR (COSY, HSQC, HMBC, and NOESY), MS experiments, and a chemical reduction of hydroperoxide by triphenylphosphine. The anti-inflammatory activities of <b>1</b>-<b>  ...[more]

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