Ontology highlight
ABSTRACT:
SUBMITTER: Gerard B
PROVIDER: S-EPMC3134123 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
ACS combinatorial science 20110428 4
We have implemented an aldol-based "build/couple/pair" (B/C/P) strategy for the synthesis of stereochemically diverse 8-membered lactam and sultam scaffolds via S(N)Ar cycloetherification. Each scaffold contains two handles, an amine and aryl bromide, for solid-phase diversification via N-capping and Pd-mediated cross coupling. A sparse matrix design strategy that achieves the dual objective of controlling physicochemical properties and selecting diverse library members was implemented. The prod ...[more]