Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC3204027 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Chen Jiamin J Zhang Xiao X Lentz Cindy C Abi-Daoud Marie M Paré Geneviève C GC Yang Xiaolong X Feilotter Harriet E HE Tron Victor A VA
The American journal of pathology 20110903 5
MicroRNAs play important roles in gene regulation, and their expression is frequently dysregulated in cancer cells. In a previous study, we reported that miR-193b represses cell proliferation and regulates cyclin D1 in melanoma cells, suggesting that miR-193b could act as a tumor suppressor. Herein, we demonstrate that miR-193b also down-regulates myeloid cell leukemia sequence 1 (Mcl-1) in melanoma cells. MicroRNA microarray profiling revealed that miR-193b is expressed at a significantly lower ...[more]