MiR-193b Modulates Resistance to Doxorubicin in Human Breast Cancer Cells by Downregulating MCL-1.
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ABSTRACT:
SUBMITTER: Long J
PROVIDER: S-EPMC4615858 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
miR-193b Modulates Resistance to Doxorubicin in Human Breast Cancer Cells by Downregulating MCL-1.
Long Jingpei J Ji Zhiwei Z Jiang Kai K Wang Zhaoyang Z Meng Guanmin G
BioMed research international 20151007
MicroRNAs (miRNAs) family, which is involved in cancer development, proliferation, apoptosis, and drug resistance, is a group of noncoding RNAs that modulate the expression of oncogenes and antioncogenes. Doxorubicin is an active cytotoxic agent for breast cancer treatment, but the acquisition of doxorubicin resistance is a common and critical limitation to cancer therapy. The aim of this study was to investigate whether miR-193b mediated the resistance of breast cancer cells to doxorubicin by t ...[more]
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