Ontology highlight
ABSTRACT:
SUBMITTER: Ge S
PROVIDER: S-EPMC3214653 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20110927 41
We report the α-arylation of ketones with a range of aryl chlorides with enantioselectivities from 90 to 99% ee catalyzed by the combination of Ni(COD)(2) and (R)-BINAP and the coupling of ketones with a range of heteroaryl chlorides with enantioselectivities up to 99% ee catalyzed by Ni(COD)(2) and (R)-DIFLUORPHOS. The analogous reactions of bromoarenes occur with much lower enantioselectivities. Mechanistic studies showed that the difference in the rates of decomposition of the arylnickel(II) ...[more]