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General method for the synthesis of salicylic acids from phenols through palladium-catalyzed silanol-directed C-H carboxylation.

ABSTRACT: A silanol-directed, palladium-catalyzed C-H carboxylation reaction of phenols to give salicylic acids has been developed. This method features high efficiency and selectivity, and excellent functional-group tolerance. The generality of this method was demonstrated by the carboxylation of estrone and by the synthesis of an unsymmetrically o,o'-disubstituted phenolic compound through two sequential C-H functionalization processes.

SUBMITTER: Wang Y

PROVIDER: S-EPMC4565602 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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General method for the synthesis of salicylic acids from phenols through palladium-catalyzed silanol-directed C-H carboxylation.

Wang Yang Y Gevorgyan Vladimir V

Angewandte Chemie (International ed. in English) 20150119 7

A silanol-directed, palladium-catalyzed C-H carboxylation reaction of phenols to give salicylic acids has been developed. This method features high efficiency and selectivity, and excellent functional-group tolerance. The generality of this method was demonstrated by the carboxylation of estrone and by the synthesis of an unsymmetrically o,o'-disubstituted phenolic compound through two sequential C-H functionalization processes. ...[more]

PMID: 25597502

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