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A benzothiazole alkyne fluorescent sensor for Cu detection in living cell.

ABSTRACT: A new type of alkyne dye, 6-dimethylaminobenzothiazole alkyne (1), was developed for Cu sensing in biological system. Dye (1) offered excellent selective over a panel of ions, only Cu(I) could change the fluorescence of dye (I) by forming copper acetylide between the terminal alkyne and Cu(I). Its potential of detecting Cu in biological system was demonstrated in cell culture.

SUBMITTER: Qi J

PROVIDER: S-EPMC3274586 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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A benzothiazole alkyne fluorescent sensor for Cu detection in living cell.

Qi Jianjun J Han Myung Shin MS Tung Ching-Hsuan CH

Bioorganic & medicinal chemistry letters 20120111 4

A new type of alkyne dye, 6-dimethylaminobenzothiazole alkyne (1), was developed for Cu sensing in biological system. Dye (1) offered excellent selective over a panel of ions, only Cu(I) could change the fluorescence of dye (I) by forming copper acetylide between the terminal alkyne and Cu(I). Its potential of detecting Cu in biological system was demonstrated in cell culture. ...[more]

PMID: 22297113

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