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Palladium-catalyzed N-arylation of 2-aminothiazoles.

ABSTRACT: A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loading. Furthermore, an interesting effect of acetic acid as an additive is uncovered that facilitates catalyst activation.

SUBMITTER: McGowan MA

PROVIDER: S-EPMC3319723 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Palladium-catalyzed N-arylation of 2-aminothiazoles.

McGowan Meredeth A MA Henderson Jaclyn L JL Buchwald Stephen L SL

Organic letters 20120306 6

A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loading. Furthermore, an interesting effect of acetic acid as an additive is uncovered that facilitates catalyst activation. ...[more]

PMID: 22394197

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