Insight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat.
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ABSTRACT:
SUBMITTER: Surmeli NB
PROVIDER: S-EPMC3477619 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Publications
Insight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat.
Surmeli Nur Basak NB Marletta Michael A MA
Chembiochem : a European journal of chemical biology 20120330 7
Nitric oxide (NO) signaling mediates many important physiological processes through the receptor soluble guanylate cyclase (sGC). Under disease conditions sGC heme can be oxidized resulting in NO insensitivity. Here, we show that the therapeutic compound cinaciguat (Cin) rescues dysfunctional sGC by direct displacement of the oxidized heme. ...[more]
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