Ontology highlight
ABSTRACT:
SUBMITTER: Sims-Robinson C
PROVIDER: S-EPMC3699525 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Sims-Robinson Catrina C Hur Junguk J Hayes John M JM Dauch Jacqueline R JR Keller Peter J PJ Brooks Susan V SV Feldman Eva L EL
PloS one 20130702 7
While oxidative stress is implicated in aging, the impact of oxidative stress on aging in the peripheral nervous system is not well understood. To determine a potential mechanism for age-related deficits in the peripheral nervous system, we examined both functional and morphological changes and utilized microarray technology to compare normal aging in wild-type mice to effects in copper/zinc superoxide dismutase-deficient (Sod1(-/-)) mice, a mouse model of increased oxidative stress. Sod1(-/-) m ...[more]