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Cytotoxic and anti-inflammatory metabolites from the soft coral Scleronephthya gracillimum.

ABSTRACT: Five new pregnane-type steroids, sclerosteroids J-N (1-5), and a diterpenoid with a new chemotype 3-methyl-5-(10'-acetoxy-2',6',10'-trimethylundecyl)-2-penten-5-olide (6), have been isolated from a soft coral Scleronephthya gracillimum. The structures of the metabolites were determined by extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against HepG2, A549, and MDA-MB-231 cancer cell lines. Furthermore, steroids 2 and 4 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein, and 1, 2, 4 and 5 could effectively reduce the accumulation of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells.

SUBMITTER: Fang HY

PROVIDER: S-EPMC3721209 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature

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Cytotoxic and anti-inflammatory metabolites from the soft coral Scleronephthya gracillimum.

Fang Hui-Yu HY Hsu Chi-Hsin CH Chao Chih-Hua CH Wen Zhi-Hong ZH Wu Yang-Chang YC Dai Chang-Feng CF Sheu Jyh-Horng JH

Marine drugs 20130529 6

Five new pregnane-type steroids, sclerosteroids J-N (1-5), and a diterpenoid with a new chemotype 3-methyl-5-(10'-acetoxy-2',6',10'-trimethylundecyl)-2-penten-5-olide (6), have been isolated from a soft coral Scleronephthya gracillimum. The structures of the metabolites were determined by extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against HepG2, A549, and MDA-MB-231 cancer cell lines. Furthermore, steroids 2 and 4 were found to significantly inhibit the accumulation of t ...[more]

PMID: 23760015

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