Ontology highlight
ABSTRACT:
SUBMITTER: Jin T
PROVIDER: S-EPMC3729158 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Jin Tengchuan T Huang Mo M Smith Patrick P Jiang Jiansheng J Xiao T Sam TS
Acta crystallographica. Section F, Structural biology and crystallization communications 20130727 Pt 8
The caspase-recruitment domain (CARD) mediates homotypic protein-protein interactions that assemble large oligomeric signaling complexes such as the inflammasomes during innate immune responses. Structural studies of the mammalian CARDs demonstrate that their six-helix bundle folds belong to the death-domain superfamily, whereas such studies have not been reported for other organisms. Here, the zebrafish interferon-induced guanylate-binding protein 1 (zIGBP1) was identified that contains an N-te ...[more]