Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh A
PROVIDER: S-EPMC3861124 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Ghosh Aniket A Kling Tina T Snaidero Nicolas N Sampaio Julio L JL Shevchenko Andrej A Gras Heribert H Geurten Bart B Göpfert Martin C MC Schulz Jörg B JB Voigt Aaron A Simons Mikael M
PLoS genetics 20131212 12
Glia are of vital importance for all complex nervous system. One of the many functions of glia is to insulate and provide trophic and metabolic support to axons. Here, using glial-specific RNAi knockdown in Drosophila, we silenced 6930 conserved genes in adult flies to identify essential genes and pathways. Among our screening hits, metabolic processes were highly represented, and genes involved in carbohydrate and lipid metabolic pathways appeared to be essential in glia. One critical pathway i ...[more]