Ontology highlight
ABSTRACT:
SUBMITTER: Heil P
PROVIDER: S-EPMC3872288 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Heil Patrick P Spatz Joachim P JP
Journal of physics. Condensed matter : an Institute of Physics journal 20100426 19
Focal adhesions (FAs) are important adhesion sites between eukaryotic cells and the extracellular matrix, their size depending on the locally applied force. To quantitatively study the mechanosensitivity of FAs, we induce their growth and disassembly by varying the distribution of intracellular stress. We present a novel method for micromanipulation of living cells to explore the dynamics of focal adhesion (FA) assembly under force. Fibroblasts are sheared laterally to their adhesion surface wit ...[more]