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Aminofluorination of 2-alkynylanilines: a Au-catalyzed entry to fluorinated indoles.

ABSTRACT: The scope and limitations of gold-catalyzed tandem cycloisomerization/fluorination reactions of unprotected 2-alkynylanilines to have access to 3,3-difluoro-2-aryl-3H-indoles and 3-fluoro-2-arylindoles are described. An unprecedented aminoauration/oxidation/fluorination cascade reaction of 2-alkynylanilines bearing a linear alkyl group on the terminal triple bond is reported.

SUBMITTER: Arcadi A

PROVIDER: S-EPMC3943415 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Aminofluorination of 2-alkynylanilines: a Au-catalyzed entry to fluorinated indoles.

Arcadi Antonio A Pietropaolo Emanuela E Alvino Antonello A Michelet Véronique V

Beilstein journal of organic chemistry 20140220

The scope and limitations of gold-catalyzed tandem cycloisomerization/fluorination reactions of unprotected 2-alkynylanilines to have access to 3,3-difluoro-2-aryl-3H-indoles and 3-fluoro-2-arylindoles are described. An unprecedented aminoauration/oxidation/fluorination cascade reaction of 2-alkynylanilines bearing a linear alkyl group on the terminal triple bond is reported. ...[more]

PMID: 24605165

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