Ontology highlight
ABSTRACT:
SUBMITTER: Fan YM
PROVIDER: S-EPMC3983598 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Fan Yue-Mei YM Hernesniemi Jussi J Oksala Niku N Levula Mari M Raitoharju Emma E Collings Auni A Hutri-Kähönen Nina N Juonala Markus M Marniemi Jukka J Lyytikäinen Leo-Pekka LP Seppälä Ilkka I Mennander Ari A Tarkka Matti M Kangas Antti J AJ Soininen Pasi P Salenius Juha Pekka JP Klopp Norman N Illig Thomas T Laitinen Tomi T Ala-Korpela Mika M Laaksonen Reijo R Viikari Jorma J Kähönen Mika M Raitakari Olli T OT Lehtimäki Terho T
Scientific reports 20140411
Upstream transcription factor 1 (USF1) allelic variants significantly influence future risk of cardiovascular disease and overall mortality in females. We investigated sex-specific effects of USF1 gene allelic variants on serum indices of lipoprotein metabolism, early markers of asymptomatic atherosclerosis and their changes during six years of follow-up. In addition, we investigated the cis-regulatory role of these USF1 variants in artery wall tissues in Caucasians. In the Cardiovascular Risk i ...[more]