Ontology highlight
ABSTRACT:
SUBMITTER: Ikenoue T
PROVIDER: S-EPMC4020073 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20140421 18
Amyloid fibrils form in supersaturated solutions via a nucleation and growth mechanism. Although the structural features of amyloid fibrils have become increasingly clearer, knowledge on the thermodynamics of fibrillation is limited. Furthermore, protein aggregation is not a target of calorimetry, one of the most powerful approaches used to study proteins. Here, with β2-microglobulin, a protein responsible for dialysis-related amyloidosis, we show direct heat measurements of the formation of amy ...[more]