Ontology highlight
ABSTRACT:
SUBMITTER: Squires AH
PROVIDER: S-EPMC4039743 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Squires Allison H AH Hersey Joseph S JS Grinstaff Mark W MW Meller Amit A
Journal of the American Chemical Society 20131101 44
Solid-state nanopores show promise as single-molecule sensors for biomedical applications, but to increase their resolution and efficiency, analyte molecules must remain longer in the nanopore sensing volume. Here we demonstrate a novel, facile, and customizable nanopore sensor modification that reduces the double-stranded DNA translocation velocity by 2 orders of magnitude or more via interactions outside the nanopore. This is achieved by electrospinning a copolymer nanofiber mesh (NFM) directl ...[more]