Ontology highlight
ABSTRACT:
SUBMITTER: Jou I
PROVIDER: S-EPMC5647626 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Biophysical journal 20171001 8
We have investigated the dynamics of single-stranded DNA as it translocates through charge-mutated protein nanopores. Translocation of DNA is a crucial step in nanopore-based sequencing platforms, where control over translocation speed remains one of the main challenges. Taking advantage of the interactions between negatively charged DNA and positively charged amino acid residues, the translocation speed of DNA can be manipulated by deliberate charge decorations inside the nanopore. We employed ...[more]