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Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.


ABSTRACT: To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P < 5 × 10(-6)) in an additional 1,099 cases and 2,913 controls. We identified three new susceptibility loci at 10q25.2 (rs7086803, P = 3.54 × 10(-18)), 6q22.2 (rs9387478, P = 4.14 × 10(-10)) and 6p21.32 (rs2395185, P = 9.51 × 10(-9)). We also confirmed associations reported for loci at 5p15.33 and 3q28 and a recently reported finding at 17q24.3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking.

SUBMITTER: Lan Q 

PROVIDER: S-EPMC4169232 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.

Lan Qing Q   Hsiung Chao A CA   Matsuo Keitaro K   Hong Yun-Chul YC   Seow Adeline A   Wang Zhaoming Z   Hosgood H Dean HD   Chen Kexin K   Wang Jiu-Cun JC   Chatterjee Nilanjan N   Hu Wei W   Wong Maria Pik MP   Zheng Wei W   Caporaso Neil N   Park Jae Yong JY   Chen Chien-Jen CJ   Kim Yeul Hong YH   Kim Young Tae YT   Landi Maria Teresa MT   Shen Hongbing H   Lawrence Charles C   Burdett Laurie L   Yeager Meredith M   Yuenger Jeffrey J   Jacobs Kevin B KB   Chang I-Shou IS   Mitsudomi Tetsuya T   Kim Hee Nam HN   Chang Gee-Chen GC   Bassig Bryan A BA   Tucker Margaret M   Wei Fusheng F   Yin Zhihua Z   Wu Chen C   An She-Juan SJ   Qian Biyun B   Lee Victor Ho Fun VH   Lu Daru D   Liu Jianjun J   Jeon Hyo-Sung HS   Hsiao Chin-Fu CF   Sung Jae Sook JS   Kim Jin Hee JH   Gao Yu-Tang YT   Tsai Ying-Huang YH   Jung Yoo Jin YJ   Guo Huan H   Hu Zhibin Z   Hutchinson Amy A   Wang Wen-Chang WC   Klein Robert R   Chung Charles C CC   Oh In-Jae IJ   Chen Kuan-Yu KY   Berndt Sonja I SI   He Xingzhou X   Wu Wei W   Chang Jiang J   Zhang Xu-Chao XC   Huang Ming-Shyan MS   Zheng Hong H   Wang Junwen J   Zhao Xueying X   Li Yuqing Y   Choi Jin Eun JE   Su Wu-Chou WC   Park Kyong Hwa KH   Sung Sook Whan SW   Shu Xiao-Ou XO   Chen Yuh-Min YM   Liu Li L   Kang Chang Hyun CH   Hu Lingmin L   Chen Chung-Hsing CH   Pao William W   Kim Young-Chul YC   Yang Tsung-Ying TY   Xu Jun J   Guan Peng P   Tan Wen W   Su Jian J   Wang Chih-Liang CL   Li Haixin H   Sihoe Alan Dart Loon AD   Zhao Zhenhong Z   Chen Ying Y   Choi Yi Young YY   Hung Jen-Yu JY   Kim Jun Suk JS   Yoon Ho-Il HI   Cai Qiuyin Q   Lin Chien-Chung CC   Park In Kyu IK   Xu Ping P   Dong Jing J   Kim Christopher C   He Qincheng Q   Perng Reury-Perng RP   Kohno Takashi T   Kweon Sun-Seog SS   Chen Chih-Yi CY   Vermeulen Roel R   Wu Junjie J   Lim Wei-Yen WY   Chen Kun-Chieh KC   Chow Wong-Ho WH   Ji Bu-Tian BT   Chan John K C JK   Chu Minjie M   Li Yao-Jen YJ   Yokota Jun J   Li Jihua J   Chen Hongyan H   Xiang Yong-Bing YB   Yu Chong-Jen CJ   Kunitoh Hideo H   Wu Guoping G   Jin Li L   Lo Yen-Li YL   Shiraishi Kouya K   Chen Ying-Hsiang YH   Lin Hsien-Chih HC   Wu Tangchun T   Wu Yi-Long YL   Yang Pan-Chyr PC   Zhou Baosen B   Shin Min-Ho MH   Fraumeni Joseph F JF   Lin Dongxin D   Chanock Stephen J SJ   Rothman Nathaniel N  

Nature genetics 20121111 12


To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P < 5 × 10(-6)) in an additional 1,099 cases and 2,913 controls. We identified three n  ...[more]

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