Ontology highlight
ABSTRACT:
SUBMITTER: Meneses E
PROVIDER: S-EPMC4183824 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20140813 40
Much of our knowledge of protein binding pathways is derived from extremely stable complexes that interact very tightly, with lifetimes of hours to days. Much less is known about weaker interactions and transient complexes because these are challenging to characterize experimentally. Nevertheless, these types of interactions are ubiquitous in living systems. The combination of NMR relaxation dispersion Carr-Purcell-Meiboom-Gill (CPMG) experiments and isothermal titration calorimetry allows the q ...[more]