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Regioselective C-H bond amination by aminoiodanes.

ABSTRACT: A new approach for the direct amination of 2-phenylpyridine derivatives using a diphthalimide-iodane and copper triflate has been developed. A series of different 2-phenylpyridine derivatives were aminated with yields up to 88%. Mechanistic investigations indicate that the reaction proceeds via a copper-mediated single electron transfer.

SUBMITTER: Kantak AA

PROVIDER: S-EPMC4346094 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

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Regioselective C-H bond amination by aminoiodanes.

Kantak Abhishek A AA Marchetti Louis L DeBoef Brenton B

Chemical communications (Cambridge, England) 20150201 17

A new approach for the direct amination of 2-phenylpyridine derivatives using a diphthalimide-iodane and copper triflate has been developed. A series of different 2-phenylpyridine derivatives were aminated with yields up to 88%. Mechanistic investigations indicate that the reaction proceeds via a copper-mediated single electron transfer. ...[more]

PMID: 25632832

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